The importance of TREGS in regulating immune tolerance has been proven by many studies. A connection between a reduced number of TREGS in the uterus and complications such as infertility, recurrent miscarriage and preeclampsia have been found.
The first activation of the TREGS occurs through paternal antigens in the sperm and cause these cells to activate and multiply even before the embryo has implanted. Additionally, high levels of TGF-β and prostaglandin E2, which are important for the activation of CD4 + CD25 + cells, can be found in the sperm.
We concluded that a decreased number of TREGS leads to lymphocyte activation, which in turn could lead to rejection of the foetus. Administering HGC into the uterine cavity can significantly improve the result of IVF; HCG plays a decisive role in the interaction between the embryo and the uterine lining. We at the Kinderwunsch Institut Dr Loimer can determine the TREGS or a regulatory T-cell diagnosis at any time and offer targeted therapy in the event of an abnormal finding.
Source: Gynaecologic Endocrinology and Reproductive Medicine Published: 17 November 2018 Increased implantation rate after intrauterine infusion of a small volume of human chorionic gonadotropin at the time of embryo transfer: a randomized, double-blind controlled study Pitak Laokirkkiat.