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STRUCTURE OF THE UTERUS LINING (ENDOMETRIUM)


An embryo needs the best possible conditions for implantation into the uterus; this requires the good composition of the uterine lining (endometrium). The growth of uterine lining is caused by estrogen produced by the maturing follicles. But simply administering estrogen often does not have the same effect. Especially when estrogen is administered during the stimulation phase of an IVF cycle.

Therefore, we are looking for new methods to improve the structure of the uterus lining; the implantation of an embryo takes place only sporadically when the endometrium has a thickness of less than 7mm.

One new hope comes in the form of platelet rich plasma – PRP
The blood plasma with concentrated platelets contains bioactive proteins, cytokines and other factors (TGF-β, IGF-1, EGF etc.) that promote the growth, migration and transformation of cells. The positive influence of intrauterine PRP on the uterine lining and implantation of the embryo has been found in various studies.

Platelet rich plasma is produced from the woman’s blood, so rejections or allergies are practically excluded. Growth factors naturally repair body tissues. We use PRP when the patients uterine lining does not reach 7mm thickness prior to embryo transfer. In these cases - but also with Asherman Syndrome – we at the Kinderwunsch Institut Dr Loimer have achieved very good results and can understand the scientific research.

  • Aspirin can also help uterine lining that is too thin, but the scientific research has still not been proven. Only improved implantation and blood flow to the uterus could be demonstrated.
  • Vitamin E and pentoxifylline are able to widen blood vessels and thereby improve blood flow to the tissues. There are no convincing studies in this field, albeit there are interesting reports on individual patients and small groups of patients.
  • A recent study on the use of Viagra vaginally to improve the growth of uterine lining shows a significant improvement in the lining and pregnancy rate. However, this is not an established treatment with proven effectiveness.